The effectiveness of Seroquel in the therapy of schizophrenia in teenagers (13-- 17 years of age) was demonstrated in a 6-week, double-blind, placebo-controlled trial (research study 4). Clients which satisfied DSM-IV diagnostic standards for schizophrenia were randomized into among three treatment teams: Seroquel 400 mg/day (n = 73), Seroquel 800 mg/day (n = 74), or sugar pill (n = 75). Study medicine was started at 50 mg/day as well as on day 2 increased to 100 mg/per day (split and also provided 2 or 3 times each day). Subsequently, the dosage was titrated to the target dose of 400 mg/day or 800 mg/day using increments of 100 mg/day, divided and also provided 2 or 3 times daily. The main efficacy variable was the mean adjustment from baseline in total Positive and also Negative Syndrome Scale (PANSS).
Seroquel at 400 mg/day as well as 800 mg/day transcended to placebo in the decrease of PANSS complete score. The main efficacy outcomes of this research in the therapy of schizophrenia in adolescents exists in Table 19.
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The efficacy of Seroquel in the severe treatment of psychotic episodes was established in 3 placebo-controlled tests in individuals that met DSM-IV criteria for bipolar I condition with manic episodes. These trials included individuals with or without psychotic attributes as well as excluded people with fast cycling as well as mixed episodes. Of these tests, 2 were monotherapy (12 weeks) as well as 1 was accessory therapy (3 weeks) to either lithium or divalproex. Key results in these trials were change from baseline in the Young Mania Rating Scale (YMRS) score at 3 and also 12 weeks for monotherapy and at 3 weeks for complement therapy. Accessory therapy is specified as the simultaneous initiation or succeeding management of Seroquel with lithium or divalproex.
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